| Pair Name | Solamargine, Gefitinib | ||
| Phytochemical Name | Solamargine (PubChem CID: 73611 ) | ||
| Anticancer drug Name | Gefitinib (PubChem CID: 123631 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Solamargine, Gefitinib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | IGFBP1 | hsa3484 |
| Up-regulation | Expression | SP1 | hsa6667 | |
| Result | We confirmed that SM significantly enhanced the anticancer effect of EGFR-TKIs by regulating the MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway. This study unravels a novel mechanism and suggests a new potential NSCLC-associated therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer. Carcinogenesis. 2023 Aug 18;44(6):497-510. doi: 10.1093/carcin/bgad028. | Click |
